By Ángel García-Alonso, Yotis Senis
The aim of the publication is to introduce platelets, and their sensible position in thrombotic and heart problems, justifying the relevance of platelet proteomics study. concentration then shifts to the hot advancements on mass spectrometry (MS)-based proteomics. This bankruptcy indicates power purposes for platelet proteomics now not but carried out. It comprises examples of post-translational changes (PTMs) research in platelets.
The moment a part of the booklet makes a speciality of the most study performed up to now on platelet proteomics. This comprises common proteome mapping via non-gel established separation equipment (MudPit), research of the overall platelet proteome and signaling cascades by way of gel-based separation tools (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). eventually, the final part hyperlinks the platelet transcriptome and alertness to disease. This part is extremely suitable and comprises chapters on proteomics, transcriptomics, sensible genomics, platforms biology, and their functions to platelet-related diseases.
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