By Michael Sela
The Antigens, quantity VI is a entire treatise overlaying all facets of antigens, together with their chemistry and biology in addition to their immunologic position and expression. Parasite antigens and their immunogenicity in contaminated hosts are explored, besides the character of the antibody-combining web site and the phenomenon of immunological tolerance.
Comprised of 3 chapters, this quantity starts off with a dialogue at the dynamic facets of the functionality of antibodies, paying specific recognition to the constitution of immunoglobulins and the folding in their domain names; the dynamics of segmental flexibility; the kinetics of antibody-hapten organization and the kinetic expression of basic interplay; and the conformational transitions in the antibody molecule triggered through hapten binding. the subsequent bankruptcy makes a speciality of the immunogenicity of parasite antigens in contaminated hosts, bringing up such parasites as trypanosomes, Schistosoma mansoni, and Fasciola hepatica. The final bankruptcy offers with immunological tolerance, its induction and length, and its impression at the specificity of the immune response.
This monograph can be of curiosity to practitioners and researchers in immunology, experimental and scientific drugs, biochemistry, and different disciplines.
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