Download E-books The G Protein-Coupled Receptors Handbook (Contemporary Clinical Neuroscience) PDF

By Lakshmi A. Devi (Ed.), Lakshmi A. Devi

A finished survey of the numerous contemporary advances within the box of G protein-coupled receptors (GPCR). The authors describe the present wisdom of GPCR receptor constitution and serve as, different mechanisms excited about the rules of GPCR functionality, and the position of pharmacological chaperones in GPCR folding and maturation. additionally they current new findings approximately how GPCR dimerization/oligomerization modifies the houses of person receptors and convey how contemporary advancements are resulting in major advances in drug discovery, comparable to the detection of ligands for orphan GPCRs. additionally mentioned are the newest advancements that may bring about new drug discoveries: the function of GPCRs in mediating ache, the improvement of receptor-type selective medications according to the structural plasticity of receptor activation, and the identity of typical ligands of orphan GPCRs (deorphanization) as attainable drug ambitions.

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